Anti-Aging Drugs: Metformin, Fisetin, Rapamycin, Resveratrol

Mar 21, 2022News

Resveratrol, rapamycin, fisetin, and metformin are being tested in clinical trials for age-related diseases with promise in rejuvenation and longevity.

Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and the environment. Many age-associated diseases require dietary restrictions to slow down harmful effects. Extensive research is ongoing to investigate the mechanism of aging and identify molecules that slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. There is evidence supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction and may share common downstream targets with rapamycin and metformin. Resveratrol, rapamycin, fisetin, and metformin are currently tested in clinical trials or under development for age-related diseases and are propagated to fulfill one or even all of the promises in terms of healthspan, rejuvenation, and longevity.



Metformin, an FDA-approved first-line drug for the treatment of Type 2 diabetes, has known beneficial effects on glucose metabolism. Evidence from animal models and in vitro studies suggest that in addition to its effects on glucose metabolism, metformin may influence metabolic and cellular processes associated with the development of age-related conditions, such as inflammation, oxidative damage, diminished autophagy, cell senescence, and apoptosis.

Anti-aging grugs for longevity

As such, metformin is a subject of particular interest in clinical translational research in aging since it may influence fundamental aging factors that underlie multiple age-related conditions. The investigators, therefore, propose a pilot study to examine the effect of metformin treatment on the biology of aging in humans. Namely, whether treatment with metformin will restore the gene expression profile of older adults with impaired glucose tolerance (IGT) to that of young, healthy subjects.

Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Taking certain other medications with metformin may increase the risk of lactic acidosis. 

If you are interested in the latest YouTube videos, publications, and events related to longevity, just click on the corresponding words, and you will be redirected to the associated web pages.

Metformin and Aging: A Review

Metformin promotes lifespan

Metformin: A Hopeful Promise in Aging Research

Side Effects of Metformin: What You Should Know

Clinical perspectives and concerns of metformin as an anti-aging drug

Is metformin the key to anti-aging?

Metformin treatment is associated with an increase in bone mineral density in type 2 diabetes mellitus patients in China: A retrospective single center study

Effect of metformin on intact mitochondria from liver and brain: Concept revisited


Where to buy Metformin?

Metformin is a prescription drug and thus needs to be acquired through a doctor’s prescription, at least in most countries. It is not considered a longevity drug and is prescribed for blood sugar control issues (type 2 diabetes). Thus, you may need to find a forward-thinking doctor if you want it prescribed for general health.

However, there are some online sources that can help you with that. Be sure to obey dosage and follow instructions.

Online sources:  AgelessRx,,  or Blink Health.

Currently, the anti-aging effect of metformin is being investigated. The Targeting Aging with Metformin (TAME) Trial is a series of nationwide, six-year clinical trials that will test whether those taking metformin experience delayed development or progression of age-related chronic diseases—such as heart disease, cancer, and dementia.

Anti-aging grugs for longevity


Fisetin is a naturally occurring substance found in fruits and vegetables, such as strawberries, apples, grapes, onions, and cucumbers. It is a flavonoid. Science teams are currently exploring its ability to slow the aging process and extend lifespan – its so-called “senolytic” effects. Some studies identify the flavonoid polyphenol fisetin as having greater senotherapeutic activity in cultured cells than quercetin. What’s more, fisetin has powerful anti-inflammatory, antioxidant, and immune-supporting properties. Moreover, preclinical studies show the potential of fisetin to reduce the impact of stroke, mild cognitive impairment, and dementia.

FISETIN: A Senolytic In The Fight To Defeat Aging

Fisetin and Longevity

New Perspectives for Fisetin

Fisetin Potential Benefits + Foods, Dosage & Side Effects

Fisetin is a senotherapeutic that extends health and lifespan

Fisetin: A Dietary Antioxidant for Health Promotion

Fisetin Has Anti-Aging Activity in Human Tissues and Extends Mouse Lifespan


Where to buy Fisetin?

Fisetin is typically sold in capsules, which can be taken with food/fat sources. You can order it online from trusted sources: LifeExtention, Numax, or Double Wood Supplements.



Resveratrol is a polyphenol, a naturally occurring, highly powerful antioxidant. Although you can find it in peanuts, blueberries, and cranberries, it’s most prominent in the skin of grapes and shines through in natural grape juice and red wine.

Anti-aging grugs for longevity

Resveratrol is becoming a popular antiaging supplement; in fact, perhaps a better name for it would be resveratrol as it has shown it can extend lifespan in several lab studies. Resveratrol also demonstrates anti-inflammatory and anticarcinogenic properties, and can lower blood pressure, improve heart health and boost cognition.

Resveratrol is a safe supplement, but there have been some negative effects reported in a small number of cases.

Lifespan and healthspan extension by resveratrol

Resveratrol – The new fountain of youth?

A Complete Guide to Resveratrol: The Secret Weapon to Slow Aging

Growing evidence links resveratrol to extended life span

Resveratrol – The small molecule with big antiaging ideas

Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases

Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1/FoxO1


Where to buy Resveratrol?

Resveratrol has been shown to enhance NAD+ synthesis and increase intracellular NAD+ levels. You can order it online from trusted sources like Life Extention, Luma Nutrition, Double Wood Supplements, ProHealth Longevity, MegaResveratrol, or RevGenetics.

Anti-aging grugs for longevity


If you like the idea of living as long as possible, rapamycin may be the drug for you. It is also known as Rapamune or Sirolimus. Originally developed as an immunosuppressant for organ transplant patients, it has found a new lease on life as a potential anti-aging drug. It recently became one of the most promising anti-aging substances and showed positive effects on health in old age. So far, it is the only pharmacological agent shown to reproducibly extend lifespan and delay a subset of age-associated pathologies in multiple strains of mice. A recent study from Drexel University discovered that rapamycin showed promising anti-aging properties on aging human tissue, specifically skin. The drug had shown early promise and was thought to work by slowing down immunosenescence, or the age-related decline of the immune system. Moreover, by inhibiting mTOR, rapamycin mimics calorie restriction and fasting.

Effect of rapamycin on aging and age-related diseases—past and future

Rapamycin and aging: When, for how long, and how much?

Is Rapamycin the New “Fountain of Youth”?

Rapamycin for longevity: opinion article

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Anti-Aging Drug Candidate Rapamycin Alters How DNA Is Stored

The Rapamycin Story

A Solution to Alzheimer’s and Aging? Rapamycin and it’s potential.

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan

Rapamycin Frequently Asked Questions (FAQ)

Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells

Where to buy Rapamycin?

You need a doctor’s prescription for this one. You can use the information on the Rapamycin News website.

What is next?

New information on longevity supplements will be updated periodically. Be sure to check back!

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This website is dedicated to all aspects of longevity with educational and inspirational purposes only. Understanding of the biological basis of aging is important since it gives us ideas on how to slow down and, possibly, even reverse the changes in our bodies leading to aging and illnesses.

We accumulate so-called positive traits of old age during our whole life, such as knowledge, experience, wisdom, empathy, and freedom. Too late! We are approaching our time to die. However, it doesn’t need to be this way.

If you have an opportunity to live active life longer without pain, disease, or cognitive decline, would you? Imagine a possibility to enjoy and watch your family growing beyond grandchildren, travel the world, realize your skills and experience in something you always wanted to do down to perfection. Sounds not bad, does it?

Well, according to science, it is quite possible!

Where do you stand on your longevity?

Definitely, when it comes to our body and mind, everyone has a right to a personal choice on how to maintain health, treat the problems, or take steps for further improvement. We defined three different levels for longevity approaches depending on your condition (perfectly healthy or have pre-existing conditions), your goal (maintain or improve your health), and the complexity of life extension methods (easy, moderate, or advanced).

Level 1 – Simple

You can choose to maintain or improve your health by easy and cheap methods such as healthy eating, herb therapy, or general supplement arrangements (vitamins, minerals, etc.). You can find information on these methods in our “What Can You Do” Category or go to the “Anti-aging methods and techniques” page.

Level 2 – Moderate

If you wish to take a step further, you may consider IV therapy, hyperbaric oxygen therapy, or extreme fasting. You can find information on these methods in our “What Can You Do” Category or go to the “Anti-aging methods and techniques” page. The cutting-edge achievements can be found on the “News & information” page.

Level 3 – Advanced

At this level, you must be totally dedicated to your longevity and target the most advanced treatments toward lifespan extension (regenerative medicine such as stem cell treatment, cartilage regeneration, platelet-rich plasma therapy, prolotherapy, etc.). Most of these methods are being used now and show even greater promise for the future. “News & information” page.

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