Resveratrol, rapamycin, fisetin, and metformin are being tested in clinical trials for age-related diseases with promise in rejuvenation and longevity.
Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and the environment. Many age-associated diseases require dietary restrictions to slow down harmful effects. Extensive research is ongoing to investigate the mechanism of aging and identify molecules that slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. There is evidence supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction and may share common downstream targets with rapamycin and metformin. Resveratrol, rapamycin, fisetin, and metformin are currently tested in clinical trials or under development for age-related diseases and are propagated to fulfill one or even all of the promises in terms of healthspan, rejuvenation, and longevity.
Metformin, an FDA-approved first-line drug for the treatment of Type 2 diabetes, has known beneficial effects on glucose metabolism. Evidence from animal models and in vitro studies suggest that in addition to its effects on glucose metabolism, metformin may influence metabolic and cellular processes associated with the development of age-related conditions, such as inflammation, oxidative damage, diminished autophagy, cell senescence, and apoptosis.
As such, metformin is a subject of particular interest in clinical translational research in aging since it may influence fundamental aging factors that underlie multiple age-related conditions. The investigators, therefore, propose a pilot study to examine the effect of metformin treatment on the biology of aging in humans. Namely, whether treatment with metformin will restore the gene expression profile of older adults with impaired glucose tolerance (IGT) to that of young, healthy subjects.
Metformin and Aging: A Review
Metformin promotes lifespan
Metformin: A Hopeful Promise in Aging Research
Side Effects of Metformin: What You Should Know
Clinical perspectives and concerns of metformin as an anti-aging drug
Is metformin the key to anti-aging?
Metformin treatment is associated with an increase in bone mineral density in type 2 diabetes mellitus patients in China: A retrospective single center study
Effect of metformin on intact mitochondria from liver and brain: Concept revisited
Where to buy Metformin?
Metformin is a prescription drug and thus needs to be acquired through a doctor’s prescription, at least in most countries. It is not considered a longevity drug and is prescribed for blood sugar control issues (type 2 diabetes). Thus, you may need to find a forward-thinking doctor if you want it prescribed for general health.
However, there are some online sources that can help you with that. Be sure to obey dosage and follow instructions.
Currently, the anti-aging effect of metformin is being investigated. The Targeting Aging with Metformin (TAME) Trial is a series of nationwide, six-year clinical trials that will test whether those taking metformin experience delayed development or progression of age-related chronic diseases—such as heart disease, cancer, and dementia.
Fisetin is a naturally occurring substance found in fruits and vegetables, such as strawberries, apples, grapes, onions, and cucumbers. It is a flavonoid. Science teams are currently exploring its ability to slow the aging process and extend lifespan – its so-called “senolytic” effects. Some studies identify the flavonoid polyphenol fisetin as having greater senotherapeutic activity in cultured cells than quercetin. What’s more, fisetin has powerful anti-inflammatory, antioxidant, and immune-supporting properties. Moreover, preclinical studies show the potential of fisetin to reduce the impact of stroke, mild cognitive impairment, and dementia.
Fisetin and Longevity
New Perspectives for Fisetin
Fisetin Potential Benefits + Foods, Dosage & Side Effects
Fisetin is a senotherapeutic that extends health and lifespan
Fisetin: A Dietary Antioxidant for Health Promotion
Fisetin Has Anti-Aging Activity in Human Tissues and Extends Mouse Lifespan
Where to buy Fisetin?
Resveratrol is a polyphenol, a naturally occurring, highly powerful antioxidant. Although you can find it in peanuts, blueberries, and cranberries, it’s most prominent in the skin of grapes and shines through in natural grape juice and red wine.
Resveratrol is becoming a popular antiaging supplement; in fact, perhaps a better name for it would be resveratrol as it has shown it can extend lifespan in several lab studies. Resveratrol also demonstrates anti-inflammatory and anticarcinogenic properties, and can lower blood pressure, improve heart health and boost cognition.
Resveratrol is a safe supplement, but there have been some negative effects reported in a small number of cases.
Lifespan and healthspan extension by resveratrol
Resveratrol – The new fountain of youth?
A Complete Guide to Resveratrol: The Secret Weapon to Slow Aging
Growing evidence links resveratrol to extended life span
Resveratrol – The small molecule with big antiaging ideas
Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases
Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1/FoxO1
If you like the idea of living as long as possible, rapamycin may be the drug for you. It is also known as Rapamune or Sirolimus. Originally developed as an immunosuppressant for organ transplant patients, it has found a new lease on life as a potential anti-aging drug. It recently became one of the most promising anti-aging substances and showed positive effects on health in old age. So far, it is the only pharmacological agent shown to reproducibly extend lifespan and delay a subset of age-associated pathologies in multiple strains of mice. A recent study from Drexel University discovered that rapamycin showed promising anti-aging properties on aging human tissue, specifically skin. The drug had shown early promise and was thought to work by slowing down immunosenescence, or the age-related decline of the immune system. Moreover, by inhibiting mTOR, rapamycin mimics calorie restriction and fasting.
Effect of rapamycin on aging and age-related diseases—past and future
Rapamycin and aging: When, for how long, and how much?
Is Rapamycin the New “Fountain of Youth”?
Rapamycin for longevity: opinion article
A triple drug combination targeting components of the nutrient-sensing network maximizes longevity
Anti-Aging Drug Candidate Rapamycin Alters How DNA Is Stored
The Rapamycin Story
A Solution to Alzheimer’s and Aging? Rapamycin and it’s potential.
Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles
Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis
As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan
Rapamycin Frequently Asked Questions (FAQ)
Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
Where to buy Rapamycin?
You need a doctor’s prescription for this one. You can use the information on the Rapamycin News website.
What is next?
New information on longevity supplements will be updated periodically. Be sure to check back!
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