Unlocking the Secrets of Aging: Breakthroughs from 2023

Jan 29, 2024Longevity Aspects

In recent years, there has been significant progress in anti-aging research, with scientists and researchers making groundbreaking advancements in the field of longevity.

Aging, a universal phenomenon, affects every living organism, and unraveling its mysteries has significant implications for health and longevity. The year 2023 witnessed some groundbreaking theoretical breakthroughs in the field of aging studies, setting the stage for potentially transformative advancements in the way we understand and approach aging.

In 2023 alone, more than 4,000 articles were published on aging. More than 154 studies were published on “healthspan,” a measure of not just how long we live, but how long we live in good health.

Key Takeaways on Advances:

  • Chemically Induced Reprogramming: Researchers have developed a chemical approach to reverse cellular aging.
  • Rewiring the Aging Process with Synthetic Biology: Researchers at the University of California San Diego have made significant progress in extending the lifespan of cells through synthetic biology.
  • A growing list of Aging Hallmarks: In 2013, scientists identified nine hallmarks of aging, but in 2023, they expanded the list to 12.
  • Advances in the Field of Biomarkers of Aging: In 2023, there have been several notable advances in the field of biomarkers of aging.
  • The Role of Omics in Longevity: Research in 2023 has provided significant additional insights into the role of omics in longevity.
  • What is new in Longevity Drugs: In 2023, some advances were made in the longevity drug field of research, from repurposing existing ones to adding new ones to the list with a perspective of substantial acceleration of AI-powered new drug discoveries.
  • The Future of Anti-Aging Research

 

Chemically Induced Reprogramming to Reverse Cellular Aging

The researchers at Harvard Medical School conducted a groundbreaking study on chemically induced reprogramming to reverse cellular aging, offering new possibilities in regenerative medicine and whole-body rejuvenation.

In this study, the researchers focused on screening molecules that can rejuvenate human cells and reverse the aging process at a cellular level. Through their investigation, they identified six chemical cocktails that have the potential to restore youthfulness to cells and reverse the effects of aging.

This research has identified a “chemical cocktail” that may reverse aging in mice within a week, offering the potential for whole-body rejuvenation

This discovery is a significant breakthrough in the field of anti-aging research and has the potential to revolutionize the treatment of aging, injuries, and age-related diseases. By utilizing chemically induced reprogramming, researchers aim to harness the regenerative capabilities of cells and promote whole-body rejuvenation.

chemically induced reprogramming

This groundbreaking research has opened up new possibilities for developing a single pill that can effectively reverse the aging process. Imagine the potential for improving eyesight and treating age-related diseases with a simple medication.

And now we have some even more exciting news, which is from a model that is even closer to humans. Life Biosciences, a biotechnology company advancing innovative cellular rejuvenation technologies to reverse diseases of aging, announced very promising preclinical data in nonhuman primates (NHP) for its novel gene therapy. This therapy uses a partial epigenetic reprogramming approach to restore visual function.

Rewiring the Aging Process with Synthetic Biology

Researchers at the University of California San Diego have made significant progress in extending the lifespan of cells through synthetic biology. By leveraging the power of synthetic gene circuits, they have discovered a novel approach to rewiring the aging process.

Synthetic gene circuits are artificial systems that can control the expression of genes in living cells. They can be used to create novel functions, such as sensing, computing, and responding to environmental signals, or to modify existing functions, such as metabolism, development, and immunity.

One of the groundbreaking achievements is the development of gene oscillators, clock-like devices that drive cells to periodically switch between two detrimental aged states, effectively slowing down the degeneration process.

This breakthrough in synthetic biology opens up vast possibilities for reprogramming the aging process and implementing pro-longevity strategies. The ability to manipulate gene oscillators allows scientists to intervene at the cellular level, potentially unlocking the secrets of cellular longevity. By carefully controlling the periodic switches between aged states, researchers aim to maintain cellular health and function, ultimately promoting the extension of healthy lifespans.

Rewiring the Aging Process with Synthetic Biology

Designing Synthetic Gene Circuits for Cellular Longevity

The innovative field of synthetic biology enables scientists to engineer genetic circuits that can control cellular processes.

  • Researchers envision a future where synthetic gene circuits can be tailored to different cell types and tissues, effectively rewiring the aging process in a precise and personalized manner.
  • By leveraging the power of synthetic biology, scientists can develop targeted interventions to combat age-related diseases and promote healthier aging.
  • This approach holds promise in the development of pro-longevity strategies that have the potential to enhance overall health and well-being.

 

A growing list of Aging Hallmarks

The Hallmarks of Aging is a framework that categorizes the complex process of aging into distinct yet interconnected biological mechanisms. These include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. Understanding these hallmarks is crucial as they offer insights into the biological processes that contribute to age-related diseases and deterioration.

A recent article in ACS Chemical Neuroscience provides a comprehensive overview of aging as a dynamic, time-dependent process. It highlights the gradual accumulation of cell damage and the resulting functional decline in the intrinsic ability of living organisms to regulate homeostasis, leading to increased susceptibility and vulnerability to diseases. The paper reviews major cellular and molecular hallmarks of aging and their relationships to age-related diseases and malfunctions. It analyzes recent research trends and advancements in the field of aging, with a focus on molecular, cellular, and organism-level aspects, including brain aging and health, as well as major biochemical processes associated with aging. The goal of the review is to enhance understanding of aging mechanisms and progression to address remaining challenges and potential solutions in this field​​.

In 2013, scientists identified nine hallmarks of aging that include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

In 2023, the list was expanded to include three more factors: dysbiosis, chronic inflammation, and disabled macroautophagy. These new hallmarks reflect the growing evidence that the microbiome, the immune system, and the autophagy pathway are important modulators of aging and age-related diseases.

Disabled macroautophagy

Macroautophagy is a cellular process that degrades and recycles damaged or unwanted components, such as proteins, organelles, or pathogens. Macroautophagy can help maintain cellular homeostasis, quality control, and stress resistance. Scientists have discovered that macroautophagy can decline with age, leading to the accumulation of toxic aggregates, impaired mitochondrial function, and reduced stem cell activity. They have also developed methods to enhance macroautophagy to extend lifespan, such as using pharmacological agents, genetic manipulations, or dietary interventions.

Chronic inflammation

Chronic inflammation is a persistent and low-grade activation of the immune system that can cause tissue damage and dysfunction. Chronic inflammation can be triggered by various factors, such as infections, stress, obesity, or environmental toxins. Scientists have shown that chronic inflammation can promote aging by affecting the epigenome, the proteome, the mitochondria, and the stem cells. They have also investigated anti-inflammatory strategies to delay aging, such as using drugs, natural compounds, or lifestyle modifications.

Dysbiosis

Dysbiosis refers to the imbalance or disruption of the microbial communities that inhabit our body, especially the gut. Dysbiosis can affect various aspects of health, such as metabolism, immunity, and cognition. Scientists have found that dysbiosis can accelerate aging by inducing chronic inflammation, oxidative stress, and DNA damage. They have also explored ways to manipulate the microbiome to promote healthy aging, such as using probiotics, prebiotics, fecal transplants, or dietary interventions.

 

Other Major Theoretical Breakthroughs in 2023

One of the most exciting developments was in the area of genomic instability. Researchers made strides in understanding how DNA damage accumulates with age and its impact on cellular function. This has opened up new possibilities for interventions targeting DNA repair mechanisms.

Another area of progress was in understanding stem cell exhaustion. Advancements in stem cell research have provided insights into how aging affects stem cell populations and their ability to regenerate tissues. This could pave the way for novel therapies to enhance tissue regeneration in the elderly. For example, scientists have developed a novel approach that allows stem cells to be turned into retinal ganglion cells that are capable of migrating and surviving in the eye’s retina. This approach presents a promising new treatment strategy for diseases like glaucoma, in which the loss of retinal ganglion cells caused by the disease leads to irreversible vision loss.

Epigenetic alterations also saw significant progress, with studies revealing more about how lifestyle and environmental factors can influence aging at a cellular level. These alterations are directly related to a biochemical process called methylation. Methylation significantly affects our health through gene activation, gene silencing, and regulation of cellular functioning. New findings could lead to personalized lifestyle interventions to slow down the aging process.

Significant progress was made in research in mitochondrial therapeutics, which aims to develop treatments for age-related diseases, with biotech companies focusing on strategies like mitochondrial transplantation and targeting specific proteins. Mitochondria play a crucial role in energy metabolism and its link to aging, revealing that mitochondrial dysfunction is associated with a range of diseases, including genetic disorders and neurodegenerative conditions. It highlights the complexity of understanding how mitochondrial deterioration contributes to aging, with theories evolving from mitochondrial DNA damage to broader cellular processes.  However, despite rapid advancements, a complete understanding of mitochondria’s role in aging and health remains an ongoing challenge.

Implications for the Future

These theoretical breakthroughs hold immense promise for the future. They not only enhance our understanding of the aging process but also provide a foundation for developing new strategies to combat age-related diseases. The potential for extending healthspan, the period of life spent in good health, has never been more within reach.

If you are interested in the latest YouTube videos, publications, and events related to longevity, just click on the corresponding words, and you will be redirected to the associated web pages.

Hallmarks of Aging: Causes and Consequences

Ageing as a software design flaw

Evolutionary paths to mammalian longevity through the lens of gene expression                
The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review

Aging Hallmarks and Progression and Age-Related Diseases

Devo-Aging: Intersections Between Development and Aging

Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures
Longitudinal Effects of Subjective Aging on Health and Longevity: An Updated Meta-Analysis

Here are a few statements from the “Science of Anti-Aging and Longevity Lecture 2023” by Functional Nutrition & Fitness:

  • Aging is not an inevitable process, as some animals can live for hundreds of years, leading to the idea that we can potentially find ways to extend the human lifespan.
  • Aging is a software issue due to entropy, with our genome losing information in a similar way to the loss of information in a game of telephone.
  • The Healthcare System should shift its focus from treating the symptoms of aging-related diseases to addressing the root cause of aging itself, in order to promote healthy aging and potentially extend lifespan.
  • It’s easier to slow down the aging process and turn back the clock before age-related diseases occur, rather than trying to fight them off with drugs and radiation.
  • Advances in science and technology now enable accurate predictions of an individual’s lifespan based on blood tests, opening up possibilities for personalized interventions to increase longevity.

Biomarkers selection and mathematical           modeling in biological age estimation             

DNA repair and interventions in aging perspective on “loss of epigenetic information as a cause of mammalian aging”

The Role of Omics in Longevity

Omics is a term that refers to the comprehensive analysis of various biological molecules and their interactions, such as genomics, proteomics, metabolomics, and so on. Omics in longevity are powerful tools that have provided insights into the intricate workings of organisms at a molecular level.

Omics research has been increasingly applied to the study of aging and longevity, as these fields aim to understand the molecular mechanisms that underlie the complex process of aging and the factors that influence lifespan and healthspan. Research in 2023 has provided significant additional insights into the role of omics in longevity.

An article in Ageing Research Reviews covers the application of omics, such as transcriptomics, proteomics, and metabolomics, in understanding the aging process, highlighting its innovative role in aging research.

Frontline Genomics provides a comprehensive view of aging research and the role of genomics, exploring the current state of genomics in the context of aging.

Multi-Omic Underpinnings of Epigenetic Aging and Human Longevity

Nature published a study discussing the molecular mechanisms of biological aging, emphasizing the multi-omic underpinnings of epigenetic aging and human longevity. Multi-omic methods were used to integrate genomic, transcriptomic, and metabolomic data and identify biological associations with measures of epigenetic age, lifespan, and exceptional longevity. Another article in Frontiers in Genetics discussed the omics of human aging and longevity in the post-genome era, emphasizing the need for a holistic approach and the promise of high-throughput technologies in revolutionizing the identification of biomarkers through an understanding of aging. Additionally, a review in Frontiers in Genetics described recent advances and discussed emerging omics approaches in aging research, highlighting the challenges in the integration of high-throughput data. Furthermore, a review published in Nature Reviews Genetics critically examined the current state of research into aging clocks built using omics data, which are machine learning models that learn patterns in molecular features to estimate the age of the sample source.

A Comprehensive Database for Human Aging and Longevity Studies

The National Center for Biotechnology Information (NCBI) discusses a comprehensive database that collects data focusing on aging and longevity, offering a resource to access omics data related to these fields.

Biological Age and Omics Data

An article in The Lancet Healthy Longevity discusses biological age as an integrated value of biophysiological measures, widely investigated as a biomarker of aging, and its relation to omics data.

Multi-Omics Analysis in Human Diseases

An article in MedComm discusses the applications of multi-omics analysis in human diseases, including its implications for understanding aging and longevity.

Omics in longevity research

Advances in the field of biomarkers of aging

Biomarkers of aging are indicators that can measure the biological age of an organism, which may differ from its chronological age. Biomarkers of aging can help assess the risk of age-related diseases, evaluate the effectiveness of anti-aging interventions, and understand the mechanisms of aging.

In 2023, there have been several notable advances in the field of biomarkers of aging. Most of the achievements in the field were covered at the 2023 Biomarkers of Aging Symposium. This symposium focused on sharing the latest research on biomarkers of aging and discussing key issues and advancements in the field. In general, it is becoming a premier conference on aging biomarkers, with exciting developments taking shape.

A comprehensive review of the existing biomarkers of aging and the relevant evaluation techniques was published by a group of Chinese scientists. This review covered the molecular, cellular, and physiological biomarkers of aging, and discussed their advantages, limitations, and applications.

The article on progress in biological age research discusses the assessment of biological age as an alternative to chronological age (CA) for evaluating aging in individuals. It explores various markers and methods used to construct BA models, emphasizing the importance of selecting appropriate aging biomarkers.

Challenges in Identifying Biomarkers of Aging

To prove the efficacy of interventions aimed at extending healthspan and to test life-extending approaches in humans, longevity researchers first need to agree on the best measuring tools. With the power of ’omics’, AI, and large biobanks, improved biomarkers may be forthcoming. Companies and academic researchers are rallying forces, but how far have they gotten?

A Nature article discusses the elusive nature of biomarkers of aging and the challenges researchers face in slowing the biological clock.

Researchers have offered a cohesive framework for evaluating biomarkers of aging, which could be validated across different populations and settings.

Key advances

Biomarkers and Diagnostic Significance of Organ Aging

A study published in ScienceDirect discusses constructing an index system to measure organ aging status, which could be significant for diagnosing aging-related diseases.

New Methods for Constructing Aging Biomarkers

Dr. Higgins-Chen’s laboratory is working on new methods for constructing aging biomarkers, specifically useful for longitudinal and intervention studies. Learn about the speakers and panelists

The Glasgow-Karolinska Clock

A new epigenetic clock called the Glasgow-Karolinska Clock, was developed by a team of European researchers. This clock can accurately measure biological aging in both healthy and unhealthy tissue. It was tested in a clinical setting with patients with chronic kidney disease and proven to be accurate to high standards.

The eyeAge aging clock

Researchers at the Buck Institute for Research on Aging showed that imaging of the fundus, the blood vessel-rich tissue in the retina, can be used to track human aging. This method is noninvasive, less expensive, and potentially more accurate than other aging clocks that are currently available. In addition, these retinal scans are less likely to be influenced by day-to-day fluctuations compared to other biomarkers from the blood, which are more dynamic and can be affected by meals, exercise, and other factors of daily routine. This study demonstrates the potential utility of a retinal aging clock for studying aging and age-related diseases and quantitatively measuring aging on very short time scales, opening avenues for quick and actionable evaluation of gero-protective therapeutics.

What is new in longevity drugs

Longevity drugs are substances that can extend the human lifespan and healthspan by targeting the underlying causes of aging. In 2023, some of the advances were made in the longevity drug field of research.

The FDA approved many new drugs that could benefit patients and consumers, including some that target aging and age-related diseases, such as Alzheimer’s, diabetes, and heart disease.

A review of the most promising longevity drugs to date was published, highlighting the results of animal and human trials of interventions such as rapamycin, metformin, senolytics, and NAD+ boosters.

A list of 14 longevity drugs that might extend your life was compiled, featuring natural and synthetic compounds that have shown anti-aging effects in various studies.

2023: The Breakthrough Year in NAD+ Research

In 2023, there have been several important advances in the study of NAD+ (Nicotinamide Adenine Dinucleotide) and its impact on longevity. NAD+ is a molecule that plays a vital role in cellular energy production and aging. Each of the advances in NAD+ research in 2023 represents a significant step forward in our understanding of aging and longevity. They highlight the potential of NAD+ and its precursors in various therapeutic applications, from enhancing cellular health to potentially reversing age-related declines.

Dietary Supplementation With NAD+-Boosting Compounds

The impact of NAD+ on healthy longevity was the topic of a magazine article by Life Extension. The article summarized the latest research on how NAD+ supports brain, heart, and metabolic health, and how NAD+ precursors like NMN and NR could help prevent or delay age-related diseases.

A study in the Journal of Gerontology discusses how advancing age and many disease states are associated with declines in NAD+ levels. This decline in NAD+ levels with age and in various disease states has led to a focus on dietary supplementation as a potential intervention. In 2023, research has suggested that supplementing with NAD+-boosting compounds can counteract these declines, offering a practical approach to enhance cellular health and longevity. These findings are significant as they provide a non-invasive method to maintain NAD+ levels and potentially delay the onset of age-related diseases.

Long‐term NAD+ supplementation was shown to prevent the progression of age‐related hearing loss in mice.

A publication in Cold Spring Harbor Perspectives in Medicine discusses the central role of NAD+ in health and aging, including research on human progeroid and antigeroid syndromes.

The benefits and risks of NAD+ supplementation were discussed in two articles by HealthNews. One article explained how NAD+ could help fight aging by protecting against diabetes, heart disease, Alzheimer’s, and Parkinson’s. The other article addressed some of the questions and concerns that people may have about taking NAD+ supplements, such as dosage, safety, and side effects5.

A report by HealthNews ranked the top 9 options based on purity, manufacturing standards, bioavailability, and customer trust.

Current Status and Future Directions of NAD+ Precursors

A study published in Liebert Pub discusses the recent advances in understanding the beneficial effects of NAD+ precursors, highlighting the rapid increase in preclinical studies demonstrating these effects. Researchers have compiled evidence from various preclinical studies, revealing the extensive benefits of NAD+ precursors in combating age-related decline. This research not only sheds light on the molecular mechanisms behind these benefits but also paves the way for future therapeutic applications targeting aging and age-associated diseases.

Nicotinamide Riboside and Longevity

The research by Romanian scientists highlighted in the National Center for Biotechnology Information (NCBI) suggests that Nicotinamide Riboside, a derivative of Vitamin B3, could contribute to healthy aging and longevity. Studies have shown that this NAD+ precursor can play a significant role in senotherapeutics, offering a promising avenue for extending lifespan and improving healthspan. The research underscores the importance of NAD+ in cellular health and its potential impact on slowing down the aging process.

By the way, we already wrote in our previous post about a remarkable development in the field of medical science involving the nicotinamide riboside (NR) ingredient, Niagen®, that has shown promising results in improving the lives of those affected by Ataxia Telangiectasia (AT), a rare neurodegenerative disorder.

Antiaging Effects of Nicotinamide Mononucleotide

A study published in ScienceDirect examines the safety and antiaging effects of Nicotinamide Mononucleotide (NMN), another NAD+ precursor. Research conducted on mouse models indicates that NMN supplementation can lead to increased NAD+ levels, thereby enhancing cellular health and longevity. These findings are crucial as they suggest a direct link between NAD+ levels and the reversal of aging-related declines.

Senescence Prevention with Nicotinamide Mononucleotide

NAD+ supplementation is shown to prevent senescence in by improving mitochondrial homeostasis. Loss of mitochondrial function leads to a decline in T cell function, which plays a significant role in the aging process. boosting intracellular NAD+ levels with nicotinamide mononucleotide (NMN) prevents senescence by promoting mitophagy.

The study on Nicotinamide Mononucleotide in the context of myocardiocyte longevity points out that NMN has a cornerstone in the functionality of Sirtuins, which are an essential anti-senescent intrinsic molecule. The study aimed to assess the role of NMN in the longevity and anti-senescent of myocardiocytes.

Physiological Reboot with NAD+ Precursors

The concept of reversing neuroinflammation and other aging-related issues through NAD+ precursors has gained traction in 2023. Studies suggest that these precursors can act as a ‘physiological reboot’, offering new therapeutic strategies for age-related neurological conditions. This research is particularly exciting as it opens up new possibilities for treating a range of age-associated disorders.

Impact of NAD+ Metabolism on Ovarian Aging

A study in Immunity & Ageing explores how NAD+ influences cellular aging, specifically focusing on ovarian aging. The role of NAD+ in ovarian aging has been a novel area of exploration in 2023. Research indicates that NAD+ levels significantly influence cellular aging processes, particularly in ovarian cells. The specific mechanisms by which NAD+ levels affect aging-related processes are a key area of investigation. Understanding this mechanism is crucial for developing targeted treatments for age-related fertility issues and improving overall women’s health as they age.

Kynurenine Pathway Inhibitors Combined with NAD+ Precursors

The relationship between the kynurenine pathway and longevity has been another novel discovery in 2023. Research indicates that inhibiting this pathway, in combination with NAD+ precursors, can positively impact lifespan. This approach represents a new frontier in longevity research, offering insights into how metabolic pathways interact with NAD+ metabolism to influence aging and lifespan.

The Autophagy–NAD Axis in Longevity and Disease

Research in Cell Press discusses the relationship between NAD levels, autophagy activity, and aging. The interplay between NAD levels and autophagy, a cellular cleaning process, has been a focal point of longevity research in 2023. Studies have shown that boosting either NAD levels or autophagy activity can lead to extended lifespan and improved healthspan, suggesting a synergistic relationship that could be harnessed for anti-aging therapies.

The anti-aging benefits of combining NAD+ boosters and senolytics

The interaction between NAD+ boosters and senolytics, compounds that selectively eliminate senescent cells, which are harmful cells that accumulate with age and cause inflammation and tissue damage. A review by Mayo Clinic scientists suggested that combining NAD+ boosters and senolytics could enhance the anti-aging benefits of both interventions.

Highlight the major clinical outcomes of vitamins and minerals in healthy aging: a systematic review
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan
Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity

The Interventions Testing Program (ITP)

ITP is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice. Investigators at any university, institute, company, or other organization are invited to recommend interventions for testing by submitting an application before the February deadline each year.

Essentially, it is a massive program that tests different compounds in genetically diverse mice to see if they extend their lifespan, so the main priority is looking at lifespan as opposed to health.

Aging Repurposed Drugs for Healthy Lifespan Extension

As the field of anti-aging research continues to advance, scientists have turned their attention to repurposed drugs that show promise in extending the healthy lifespan of individuals. Two such drugs that have garnered significant interest are Rapamycin and Metformin, and we already talked about them in our previous post.

Rapamycin

Rapamycin, originally developed as an immunosuppressive drug, has demonstrated impressive longevity benefits in animal studies. It has been shown to extend lifespan and improve several age-related conditions such as cardiovascular disease, cancer, and neurodegenerative disorders. It has been consistently demonstrated to increase mammalian longevity, according to a study in PubMed. This update in 2023 reinforces the drug’s status as a leading candidate in anti-aging research, with a proven track record of enhancing lifespan across various studies.

A study involving 50 women, where half received low-dose Rapamycin and half a placebo once a week for three months, is part of the ongoing research exploring Rapamycin’s potential in anti-aging. This study, covered by USA Today, highlights the growing interest in translating Rapamycin’s effects into practical anti-aging therapies.

A more extensive study involving middle-aged, large-breed dogs treated with Rapamycin for one year was set to complete enrollment in 2023. This study, highlighted in Nature, aims to understand further the impact of mTOR inhibitors like Rapamycin on aging biology, potentially offering insights into its effects on lifespan and healthspan.

Researchers are moving towards a disease-oriented approach in dosing Rapamycin, recognizing its role as a prophylactic anti-aging drug that can decelerate the early development of age-related diseases. The most popular schedule for Rapamycin administration for longevity purposes is typically 5–7 mg once a week. This schedule is based on balancing therapeutic effects and side effect avoidance, indicating a growing understanding of how to utilize Rapamycin in anti-aging treatments best. The approach aims to optimize the use of Rapamycin by tailoring doses to specific age-related conditions, potentially enhancing its effectiveness in promoting longevity.

Recent data from the ITP published by the end of 2022 showed that combining acarbose with Rapamycin led to 37% median lifespan extension in males, the best result ever produced in the ITP program. The list of most promising longevity drugs to date was updated in 2023.

Metformin

Metformin, commonly used to treat type 2 diabetes, has also shown promise in promoting healthy aging. Animal studies have revealed that Metformin can extend lifespan and delay the onset of age-related diseases such as cancer, cardiovascular disease, and cognitive decline.

Studies using data from the UK Biobank have shown that Metformin improves health and longevity in species like Caenorhabditis elegans and mice. These findings from animal models provide a basis for understanding Metformin’s potential effects on human longevity.

Research published in NCBI examines the long-term effects of Metformin on longevity, particularly in comparison to other treatments for Type 2 diabetes. This study provides insights into the benefits and limitations of Metformin in the context of aging and longevity.

The drug works by activating various molecular pathways associated with aging and age-related diseases. A 2023 study published in Nature discusses Metformin’s mechanisms of action and its potential for repurposing in longevity and anti-aging treatments. This research provides a deeper understanding of how Metformin works at the molecular level and its implications for healthspan extension.

Another study exploring Metformin’s impact on aging and longevity through DNA methylation elucidates its role in longevity through epigenetic modifications. This research is crucial in understanding the broader implications of Metformin’s mechanisms of action.

Its affordability, safety, and scientific backing make it a promising candidate for anti-aging research. The SENS Research Foundation has discussed studies on Metformin and its survival benefits that delve into the drug’s potential as a cost-effective longevity therapeutic, exploring its effects beyond its traditional use in diabetes treatment.

It is important to note that while repurposed drugs like Rapamycin and Metformin offer the potential to extend a healthy lifespan, conducting clinical trials presents challenges. Clinical trials require rigorous evaluation of the drug’s safety, dosage, and effectiveness in human subjects. Additionally, long-term studies are necessary to assess the potential side effects and overall benefits of these medications for anti-aging purposes.

Longevity Benefits of Repurposed Drugs:

  1. Extended lifespan in animal studies
  2. Improvement in age-related conditions such as cardiovascular disease, cancer, and neurodegenerative disorders
  3. Delay in the onset of age-related diseases like cancer, cardiovascular disease, and cognitive decline
  4. Activation of molecular pathways associated with aging and age-related diseases

The field of longevity research continues to investigate the potential of repurposed drugs to not only extend lifespan but also enhance the overall quality of life by reducing the severity of age-related diseases. However, more extensive research and clinical trials are needed to fully understand the benefits, risks, and optimal usage of these medications for healthy lifespan extension. With ongoing efforts, researchers aim to develop safe and effective anti-aging interventions that can help individuals enjoy a healthier and more fulfilling life.

Aging Delay with Telomerase Activators  

Telomerase activators are compounds that can increase the activity of telomerase, an enzyme that maintains the length of telomeres, which are the protective caps at the ends of our chromosomes. Telomeres naturally shorten as our cells divide and age, leading to cellular senescence and aging. The process is called telomere attrition and is known as a hallmark of aging. Actually, measurements of the length of telomeres help to determine biological age. By activating telomerase, we could potentially slow down or reverse the aging process at a cellular level.

A review focusing on telomeric aging, the molecular mechanism of action of telomerase activators, and the clinical importance of these activators in the context of increasing human lifespan and healthy aging were published in the bookEmerging Anti-Aging Strategies.” It examined the telomerase activators produced both naturally and synthetically, revealing the signaling pathways used by these activators and their clinically relevant concentrations.

A study published in PMC highlights the importance of telomere signaling in normal aging, which occurs at an average telomere length. Understanding the length of telomeres and their role in aging is crucial for developing effective longevity therapies.

The science behind activating telomerase as a cutting-edge longevity hack is explored in a post by Tomorrow Bio. Recent findings in telomerase activation are analyzed as a potential key modulator for human healthspan and longevity. This research in ScienceDirect explores the mechanisms by which telomerase activation can impact aging and longevity.

Nutraceutical Formulation Impact on Telomeres

A study demonstrated that a nutraceutical formulation containing C. asiatica extract, vitamin C, zinc, and other components can increase telomere length and improve cellular health. This research suggests that dietary supplements may play a role in telomere maintenance and longevity.

Antioxidant Glutathione Levels and Telomere Length

A study in the International Journal of Biosciences suggests that low antioxidant glutathione levels lead to longer telomeres. This finding is significant as it links oxidative stress to telomere length, a key factor in aging and longevity.

Long Telomeres and Cellular Longevity

Research from Johns Hopkins Medicine indicates that long telomeres in cells grown in the lab predict cellular longevity. However, this study suggests that in people, longer telomeres may not necessarily equate to the fountain of youth once thought. Obviously, more studies are necessary to establish the role of telomeres and their length in the aging process and healthspan.

Telomere-Targeting Therapeutics

As aging research enters a new era, a review in Frontiers emphasizes telomere-targeting therapeutics, including telomerase activators and tankyrase inhibitors. This approach represents a novel strategy in the quest for longevity, focusing on the role of telomeres in the aging process.

Lifelong Exposure to Caloric Restriction Restores the Microbiota of Aging Mice

The significance of caloric restriction mimetics as anti-aging drugs

Caloric Restriction Mimetics

Caloric Restriction Mimetics (CRM) are drugs or compounds that mimic the effects of calorie restriction (CR) without reducing food intake. CR is a dietary regimen that can extend lifespan and delay age-related diseases in various organisms. CRM research is a growing field aiming to develop healthy aging treatments. The research spans from their molecular mechanisms to their impact on specific systems like the central nervous system and the gut microbiota, highlighting their multifaceted potential in promoting health and longevity.

In 2021, a study published in ScienceDirect discussed recent advances in the field of caloric restriction mimetics and their role as anti-aging molecules. This research highlights the molecular aspects of these mimetics and their potential impact on health and longevity.

The most recent study in ScienceDirect explores the significance of caloric restriction mimetics as anti-aging drugs. The research delves into how CRMs can effectively delay aging, offering an alternative approach to traditional caloric restriction.

A Favorable Effect of CRM Drugs on Gut Microbiota

Research published in Springer highlights how calorie restriction mimetic drugs (CRM) could favorably influence gut microbiota. These drugs aim to reproduce the effects of calorie restriction, potentially prolonging human lifespan by impacting gut health, which is increasingly recognized as crucial in overall well-being and aging. The article suggested that CRM may have a dual effect on lifespan extension by influencing both the host metabolism and the gut environment. The article also proposed that CRM may act as next-generation prebiotics by increasing beneficial bacteria and decreasing harmful bacteria in the gut.

CRMs in Central Nervous System Health

A publication in NCBI focuses on the roles of caloric restriction mimetics in the central nervous system. It examines substances capable of modulating the autophagic machinery within myelinating glial cells, which is crucial for brain health and function.

CRMs for Strong Muscles

A study published in Aging Cell reported the effects of CRMs on human muscle and immune cells. The study found that they increased the number and function of mitochondria, the cellular powerhouses, in muscle cells and enhanced the anti-inflammatory response of immune cells. These findings suggest that CRMs may improve metabolic health and protect against chronic inflammation, both associated with aging and age-related diseases.

Glycolytic Inhibitors as CRM

A research article published in GeroScience explored the possibility of using glycolytic inhibitors as CRM. Glycolysis is the process of breaking down glucose for energy, and inhibiting glycolysis can mimic the metabolic state of CR. The article reviewed the evidence of glycolytic inhibitors extending lifespan and healthspan in various animal models and proposed some potential mechanisms and challenges for their application in humans.

A Growing List of Supplements for Longevity

Longevity, often referred to as anti-aging, supplements are substances that aim to extend the lifespan and healthspan of humans by targeting the biological processes of aging. An article in FortuneWell makes a suggestion that “Drugs that could treat aging might already be on the pharmacy shelves.” 

The list of best anti-aging supplements of 2023 with evidence reviews includes NAD+-boosting precursors, which we already talked about, Omega-3 fatty acids, Resveratrol and Pterostilbene (blueberries), Quercetin and Fisetin, Vitamin D3 and K2, Glycine, Taurine, Collagen, EGCG (Green Tea), CoQ10, Curcumin (Turmeric), and Molecular Hydrogen.

In 2023, significant progress was made in studies on some of these supplements.

Taurine

Taurine, an amino acid, has emerged as a promising anti-aging supplement. It is known for its various health benefits, including supporting cardiovascular health and potentially extending lifespan. It is referred to as the latest anti-aging supplement touting promising results.

The study published in Science highlights its potential anti-aging benefits, including improving heart health, acting as an antioxidant, and aiding muscle growth and DNA repair.

Resveratrol and Pterostilbene

Resveratrol and Pterostilbene are polyphenols found in grapes, berries, and peanuts. They have antioxidant and anti-inflammatory properties and can activate a family of enzymes called sirtuins, which regulate cellular stress response and longevity.

The potent antioxidant potential of Resveratrol is of particular significance because of the way it acts in the prevention and treatment of numerous chronic diseases. Pterostilbene, a naturally occurring analog of Resveratrol, has garnered significant attention due to its potential therapeutic effects in treating inflammatory and oncological diseases.

Quercetin and Fisetin

Quercetin and Fisetin are flavonoids found in fruits and vegetables, such as apples, onions, strawberries, and cucumbers. They have anti-inflammatory, antioxidant, and anti-cancer effects and can act as senolytics, drugs that selectively eliminate senescent cells. Senescent cells stop dividing and accumulate with age, contributing to chronic inflammation and tissue dysfunction. Removing them can improve health and longevity.

An article on recent advances in the potential health benefits of Quercetin was published in Pharmaceuticals, providing an overview of the chemical structure, biological activities, and bioavailability of Quercetin, as well as the different delivery systems available.

Several studies of Fisetin showed that it possesses numerous biological activities, and its treatment represents a promising therapeutic strategy for age-related diseases. The studies showed that Fisetin exerts its anti-aging effect by inhibiting the signaling pathway, leading to the apoptosis of senescent cells, demonstrating the properties of a senolytic drug.

Fisetin also holds promise as a therapeutic agent for neurological diseases and anticancer treatment.

Glycine

Glycine is a non-essential (can be produced by the body) amino acid involved in many critical cellular processes and is required in the natural production of glutathione, creatine, and collagen. Glycine decreases as we age, and decreases are associated with the development of aging-associated disorders. The evidence published in Ageing Research Reviews suggests that glycine prolongs life by mimicking methionine restriction and activating autophagy.

Moreover, dietary glycine increases healthy lifespan in model organisms and might decrease inflammation in humans, suggesting its geroprotective potential.

Vitamin D3 and K2

Experts have recommended Vitamin D as one of the top picks for anti-aging supplements, referring to it as a shield against aging. It plays a crucial role in bone health and immune function and may have protective effects against certain age-related diseases.

Vitamin K2 is a crucial nutrient family for the normal functioning of human health. It acts on almost all major body systems and directly or indirectly participates in and regulates hundreds of physiological or pathological processes. The paper published in Food Science and Nutrition provides insight into the potential beneficial roles of vitamin K2 in human health by reviewing, comparing, and contrasting available in vitro, in vivo, and clinical data.

Curcumin (Turmeric)

The recent paper in Molecules reviews the recent progress in understanding the health benefits of Curcumin. By uncovering the intricacies of Curcumin’s effects on postmitotic cells, the authors of another recent paper provide valuable insights that may ultimately contribute to the development of novel therapeutic approaches for promoting longevity and enhancing the quality of life in an aging world.

A comprehensive analysis of the role of Curcumin in the prevention and treatment of chronic diseases based on clinical trial results was presented by ACS Publications. Many studies demonstrated that Curcumin also has a beneficial role in many age-related diseases like diabetes, cardiovascular disease, neurological disorders, and cancer.

EGCG (Green Tea)

Green tea is a popular beverage associated with various health benefits, such as reducing the risk of chronic diseases and extending lifespan. A study published in Scientific Reports found that green tea may protect against telomere shortening due to biological aging. As we mentioned above, telomeres are the protective caps at the ends of chromosomes that shorten with each cell division and are linked to aging and disease. The study analyzed the association between green tea consumption and telomere length, a marker of biological aging, in over 5,000 Korean men and women for six years. The results showed that green tea drinkers had longer telomeres than non-drinkers and that the effect was stronger in women and older age groups.

A review article published in GeroScience discussed the potential role of green tea in modulating the gut microbiota, which is a key factor in health and longevity. The article suggested that green tea may have a dual effect on lifespan extension by influencing both the host metabolism and the gut environment. The article also proposed that green tea may act as next-generation prebiotics by increasing beneficial bacteria and decreasing harmful bacteria in the gut.

A magazine article published by Eat This, Not That introduced some of the ways that drinking green tea can add years to your life, according to science. The article explained how green tea can improve cardiovascular health, lower blood pressure, enhance cognitive function, prevent cancer, boost immunity, and reduce inflammation. The article also recommended drinking at least three cups of green tea daily to reap the benefits.

Molecular Hydrogen

Molecular Hydrogen (H2) is a gas that has been shown to have antioxidant, anti-inflammatory, and anti-aging effects in various studies.

A review article published in Antioxidants discussed the redox-mechanisms of molecular hydrogen and how it can modulate the cellular signaling pathways that regulate aging and longevity. The article also highlighted the potential applications of molecular hydrogen in age-related diseases, such as Alzheimer’s, Parkinson’s, cancer, and osteoporosis.

More papers on advances in studies on Molecular Hydrogen anti-aging effects and its potential for therapy and treatments are shown below.

                       Molecular Hydrogen:                             From Molecular  Effects to Stem           Cells Management and Tissue  Regeneration  

Molecular hydrogen therapy for neurological diseases: a review of current evidence
Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition
Molecular Hydrogen Therapy—A Review on Clinical Studies and Outcomes

NAM Award

The Healthy Longevity Catalyst Awards have been instrumental in rewarding early-stage projects aimed at extending the human healthspan or years spent in good health, reflecting a growing focus on addressing aging and age-related diseases.

The National Academy of Medicine (NAM) is accepting applications for the 2023 cycle of its U.S.-based Catalyst Awards. Applications will be accepted from January 23, 2023, through March 6, 2023 at 11:59 pm EST. Up to 20 awardees will each receive a cash prize of $50,000 and become part of a global network of innovators with exclusive opportunities to compete for additional funding.

 Several other programs in longevity and aging research are currently open for applications:

Advances in Other Longevity Drugs

Scientists at Osaka University have identified the protein HKDC, which plays a crucial role in maintaining mitochondria and lysosomes, preventing cellular aging, and potentially offering new avenues for age-related disease therapies.

Navitoclax is a cancer drug that inhibits BCL-2, a protein that prevents cell death. Navitoclax can also induce apoptosis, or programmed cell death, in senescent cells. A recent study revealed that navitoclax could increase the lifespan of healthy mice by three years, equivalent to 24% of their natural lifespan3.

A new study suggested that anti-diabetes drugs, such as SIT (Selective Insulin Receptor Tyrosine Kinase Inhibitors), could potentially be anti-aging medicines. This is one of the similar studies showing promise for improving longevity and promoting healthy aging listed in The Longevity Report.

The FDA has been moving closer to approving drugs for the life extension of our beloved four-legged companions. A biotech company named Loyal is at the forefront of this development, working on bringing a life-extension drug to market for dogs. A new drug called LOY-001 has been developed to extend the lifespan of large dogs. This drug is designed for dogs over seven years old and weighing more than 40 pounds. It would be administered by a veterinarian every three to six months. This development represents a significant step in veterinary medicine and could potentially have implications for human longevity research.

AI-Driven Drug Discovery

AI-driven longevity drug discovery is a field that uses artificial intelligence (AI) to find new drugs that can extend the human lifespan and healthspan. We already wrote about how AI is making longevity more accessible than ever before, including its role in drug discovery.

In 2023, some advances were made in this field, indicating a rapidly evolving landscape in AI-driven drug discovery for longevity. The integration of AI is not only accelerating the identification of potential drug candidates but also enhancing the understanding of complex aging processes, paving the way for more effective and targeted longevity therapies.

An in-depth analysis of AI’s advances in drug discovery and development in 2023 sheds light on the potential of AI in this field. This analysis discusses how AI technologies are transforming the landscape of drug discovery, particularly in longevity research. Learn more about AI trends in drug discovery.

A comprehensive overview provided by Frontiers also highlights the role of AI in longevity research. Dorian Therapeutics, for instance, developed a new class of therapeutics called “senoblockers” to rejuvenate cells and tissues, showcasing the potential of AI in identifying and developing novel longevity treatments.

A collaboration between MIT and Nvidia resulted in the development of DiffDock and BioNeMo Cloud, two AI-based tools for drug discovery. DiffDock is a method for predicting molecular docking, which is how a drug binds to a protein, using diffusion generative models. BioNeMo Cloud is a cloud service for generative AI-based drug discovery, which allows researchers to customize and deploy domain-specific, generative, and predictive biomolecular AI models at scale.

Insilico Medicine, a clinical-stage end-to-end AI-driven drug discovery company, has been connecting biology, chemistry, and digital technologies to accelerate the development of longevity drugs. Their approach exemplifies the integration of AI in streamlining the drug discovery process.

The AI in Drug Discovery West Coast 2023 summit addressing the challenges in drug discovery was held in San Francisco, CA, on September 28, 2023. It emphasized how AI can make the process faster, less expensive, and less risky. This event highlighted the growing importance of AI in developing new drugs, including those targeting aging.

AI-Powered Target Discoveries

AI has been instrumental in identifying anti-aging drug candidates targeting specific aging-related pathways. This significant milestone in longevity research demonstrates the application of AI in drug discovery, offering new avenues for developing effective anti-aging therapies.

AI has also been shown to be a powerful tool in therapeutic target discovery, revolutionizing the identification of novel drug candidates. This advancement is particularly impactful in the field of longevity, where AI is being used to uncover new targets and pathways for extending a healthy lifespan.

AI has been increasingly utilized to revolutionize the drug discovery process, making it more efficient and cost-effective. It has been employed to create the structure of new drugs, identify therapeutic targets, and facilitate drug repurposing, ultimately contributing to the development of biological markers and the identification of new targets in cells. Furthermore, AI is expected to significantly expedite drug design and development, potentially cutting the average drug development timelines by up to 4 years. The use of AI in drug discovery holds promise for accelerating the identification and development of longevity-promoting therapeutics, marking a significant advancement in the field.

A report by Boston Consulting Group explored the potential of AI in drug discovery, highlighting the key applications, maturity, barriers, and solutions of this technology. The report also featured several case studies of AI-driven drug discovery projects, including some focused on aging and age-related diseases.

The Future of Anti-Aging Research

The list of the companies, research universities and laboratories that are targeting aging and looking for the ways to slow it down or even reverse is growing every year.

The recent article titled “Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise” provides a comprehensive overview of the field of antiaging research. It highlights the historical and ongoing efforts to understand and mitigate the effects of aging, characterized by a decline in physiological fitness and an increase in cellular damage and disease susceptibility. The paper discusses various strategies for promoting healthy aging and extending lifespan, including lifestyle adjustments, medical treatments, and social programs, along with a range of antiaging medicines and remedies. The authors analyze recent research advancements and trends in antiaging strategies and treatments, assess state-of-the-art approaches, and explore their links to age-related diseases. The review aims to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, outline the challenges in this area, and evaluate growth opportunities to advance the field.

By the way, Coleen Murphy, a Professor of Molecular Biology at the Lewis-Sigler Institute for Integrative Genomics at Princeton University, just published a book, “How We Age: The Science of Longevity,” that got a comprehensive review in Nature. Murphy outlines a broad range of biological factors that can affect lifespan, including DNA damage and epigenetic modifications. She also pointed out that the molecular mechanisms that make diet and exercise beneficial are increasingly better understood, and some are the targets of existing drugs. Researchers hope to repurpose these drugs to capture some of the benefits of a healthy lifestyle.

The advancements in anti-aging research and longevity studies have paved the way for exciting breakthroughs in the field. Scientists are exploring innovative approaches, such as gene circuits and synthetic gene circuits, to slow down the aging process and promote healthier aging in complex organisms.

While extending lifespan remains a goal, researchers are also focused on improving healthspan, which is the period of life when individuals live without disability. Understanding the underlying mechanisms of aging and developing interventions to delay age-related decline aims to enhance the overall quality of life as individuals age. In pursuit of this goal, ongoing studies are investigating diverse human cell types, including stem cells and neurons, to gain a deeper understanding of longevity. These studies can provide valuable insights into the molecular processes that contribute to aging and age-related diseases, ultimately leading to the development of more effective treatments and interventions.

An article in Rejuvenation Research discusses the evolution of the field of biomedical gerontology and the transition from the “divide and conquer” approach to understanding aging to the concept of rejuvenation. It highlights the importance of two key publications, the SENS paradigm and the Hallmarks of Aging, in shaping this field. The “SENS paradigm” (Strategies for Engineered Negligible Senescence) gained adherents within the expert community by effectively countering challenges to its ideas. The “Hallmarks of Aging” survey by Lopez-Otin et al. in 2013 played a crucial role in solidifying the rejuvenation concept in the field.

According to the authors of the article in the Proceedings of the National Academy of Sciences (PNAS), the aging biology field lacks consensus on aging’s fundamental nature and essence, hindering progress and requiring focused efforts to define these key concepts. Addressing foundational questions such as the start of aging, appropriate biomarkers, and the potential reversibility of biological age is essential for advancing the field. Achieving a unified understanding of aging could resolve debates, enable collaborations, and lead to effective, equitable anti-aging interventions and public health improvements.

Human trials of potential anti-aging drugs, including metformin, NAD+/sirtuins, and rapamycin, show promising results in prolonging life and improving health. Metformin, initially a diabetes medication, has potential benefits in longevity and heart function. Compounds like NAD+ precursors and sirtuin activators are being tested for age reversal effects, with some showing improved physical performance. Other trials focus on GLP-1 receptor agonists and spermidine, which have shown effectiveness in weight loss, cardiovascular health, and cognitive function improvements.

While there is still much to discover and refine, the future of anti-aging research is filled with promise. The collective efforts of scientists worldwide have led to significant longevity achievements and the identification of novel approaches for enhancing the quality of life as we age. With further advancements, these findings can potentially revolutionize healthcare and improve human well-being on a global scale.

There are many signs that the next few years may present a tipping point when the most viable approaches will become evident and move us toward more widespread use of interventions targeting aging processes.

Seven knowledge gaps in modern biogerontology

The authors of the article in Biogerontology identified knowledge gaps in aging research with questions to be asked and answered.

1. Unclear Nature of Longevity Assurance Genes

  • The exact nature of public (universal) and private (species-specific) longevity assurance genes remains unknown.
  • These genes, involved in repair and maintenance pathways, are crucial for species-specific essential lifespans.
  • Understanding these genes is vital for comprehending lifespan differences across species.

2. Imperfections Limiting Longevity Assurance Processes

  • The exact nature of imperfections that affect longevity assurance processes is not well understood.
  • These imperfections could be critical in understanding the limitations of lifespan and healthspan.
  • Investigating whether these imperfections are sex-specific could provide deeper insights.

3. Regulation of Biological-Time Passage

  • It’s unclear how biological time is regulated through life stages until death, despite similar physical-time scales at the metabolic level.
  • Understanding this could reveal how different species experience varied rates of aging.
  • Insights into this area could revolutionize our understanding of the aging process.

4. Features of Homeodynamic Space

  • The quantitative and qualitative characteristics of the homeodynamic space, which determines health and survival ability, are not fully known.
  • Homeodynamic space involves stress response, damage control, and constant remodeling.
  • Understanding this space is crucial for comprehending how organisms maintain health and respond to aging.

5. Causes of Ageing Phenotype Heterogeneity

  • The determinants of heterogeneity in age-related changes at different biological levels are unclear.
  • This includes molecular to whole-body and population-level changes.
  • Unraveling this could explain why aging manifests differently across individuals and species.

6. Differentiating Aging Changes

  • How to distinguish between harmful, useful, and neutral changes during aging is not well understood.
  • This differentiation is essential for identifying adaptive and beneficial aspects of aging.
  • Understanding these distinctions could lead to more targeted and effective aging interventions.

7. Tolerance and Adaptation to Age-Related Changes

  • The extent to which biological systems can adapt, compensate, and tolerate age-related changes is unknown.
  • Identifying and quantifying these abilities is crucial for understanding the resilience of organisms to aging.
  • This knowledge could inform strategies for enhancing healthspan and longevity.

 

 

 

What is next?

In this post, we explored some of the main breakthroughs in anti-aging research towards longevity in 2023.

In our next posts, we will review the advances and achievements in Longevity Medicine, also known as Regenerative Medicine, in 2023, as well as new scientific proof of healthspan extension through lifestyle modifications from theoretical research and clinical trials.

We did not even talk about the herbal medicine that is making substuntial progress not only in scientific confirmation of known effects of various plants on our health and longevity but also discover new potentials. This subject deserves a separate post that is coming.

Be sure to check back!

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This website is dedicated to all aspects of longevity with educational and inspirational purposes only. Understanding of the biological basis of aging is important since it gives us ideas on how to slow down and, possibly, even reverse the changes in our bodies leading to aging and illnesses.

We accumulate so-called positive traits of old age during our whole life, such as knowledge, experience, wisdom, empathy, and freedom. Too late! We are approaching our time to die. However, it doesn’t need to be this way.

If you have an opportunity to live active life longer without pain, disease, or cognitive decline, would you? Imagine a possibility to enjoy and watch your family growing beyond grandchildren, travel the world, realize your skills and experience in something you always wanted to do down to perfection. Sounds not bad, does it?

Well, according to science, it is quite possible!

Where do you stand on your longevity?

Definitely, when it comes to our body and mind, everyone has a right to a personal choice on how to maintain health, treat the problems, or take steps for further improvement. We defined three different levels for longevity approaches depending on your condition (perfectly healthy or have pre-existing conditions), your goal (maintain or improve your health), and the complexity of life extension methods (easy, moderate, or advanced).

Level 1 – Simple

You can choose to maintain or improve your health by easy and cheap methods such as healthy eating, herb therapy, or general supplement arrangements (vitamins, minerals, etc.). You can find information on these methods in our “What Can You Do” Category or go to the “Anti-aging methods and techniques” page.

Level 2 – Moderate

If you wish to take a step further, you may consider IV therapy, hyperbaric oxygen therapy, or extreme fasting. You can find information on these methods in our “What Can You Do” Category or go to the “Anti-aging methods and techniques” page. The cutting-edge achievements can be found on the “News & information” page.

Level 3 – Advanced

At this level, you must be totally dedicated to your longevity and target the most advanced treatments toward lifespan extension (regenerative medicine such as stem cell treatment, cartilage regeneration, platelet-rich plasma therapy, prolotherapy, etc.). Most of these methods are being used now and show even greater promise for the future. “News & information” page.

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